This project aims to capitalize the resources available at the CECT, in particular the 3D printing technology used for the fabrication of bioreactors, for direct generation of patterned 3D tissues in printed bioreactors. We will work in collaboration with TR&D1 to design a 3D-printed bioreactor system that is directly compatible with a multi-material rapid stereolithographic bioprinting strategy based on our digital micromirror device (DMD) platform. Parameters will be optimized for in situ patterning of the bioink in the printed bioreactor to generate desired hydrogel structures for tissue fabrication.
Successful completion of this project will enable a new strategy to fabricate biomimetic tissues by combining all-printed components, including the microfluidic bioreactors and the volumetric miniature tissue constructs, realizing unique standardized organ model fabrication with a maximal degree of automation and reproducibility.