Innovations in metallic biomaterials have attracted remarkable attention for their potentials as orthopedic implants, cardiovascular interventional devices, and tissue engineering scaffolds, due to their high strength and toughness compared with polymers and ceramics. Traditional metallic biomaterials with high corrosion resistance, such as titanium alloys, stainless steels, and cobalt-chromium are generally permanent implants, and may cause chronic deleterious effects. Thus, a second operation may be necessary to extract the implant, resulting in additional injury and expense. Biodegradable metals (Mg, Zn, Fe) are an alternative approach to the traditional paradigm of corrosion resistant metals. They can corrode gradually while maintain mechanical integrity during the critical tissue healing phase, and fully dissolve upon fulfilling their mission. Thus, our research focuses on the emerging Zn-based biomaterials as innovative bioresorbable medical implants and devices, typically for stent, wound closure, and orthopedic applications. In association with CECT, this project will examine the mechanical, corrosion properties, and in vitro and in vivo biosafety and performances of bioresorbable metals for cardiovascular and orthopedic applications.